Red Yeast Rice Extract (also known as Xhuzikhang) is made by fermenting rice by a red yeast (Monascus purpureus). This fermentation naturally produces a group of natural statins called Monacolins, specifically Monacolin K (which molecularly is identical to lovastatin). It is able, like most statins, to reduce circulating cholesterol levels. Doctors prescribe statins to lower LDL (“bad”) cholesterol levels and help reduce the risk of heart disease. Monacolins are known to inhibit the enzyme hydroxymethylglutaryl-CoA reductase (HMG-CoA reductase), which is an enzyme that required for the biosynthesis of cholesterol (and CoQ10). Though cholesterol is necessary for many biological functions, its presence in excess levels in the blood and subsequent oxidation is considered by many cardiovascular researchers as playing a significant role in the development of coronary heart disease (CHD). Our Red Yeast Rice Extract has been used in China and other Asian countries for centuries as a traditional medicine.
The cholesterol lowering effects of red yeast rice extract (RYRE) have been known and published in scientific literature for decades. Scientists from China conducted a randomized, placebo-controlled clinical trial utilizing red yeast rice extract in the amount of 600 mg twice daily (1200 mg RYRE/day) on 60 heart disease subjects. The patients took their routine medications (i.e. Aspirin, blood pressure, etc) and added RYRE to their regimen. In the six week trial, the scientists assessed blood lipid concentrations (total cholesterol, triglyceride, HDL-cholesterol [HDL-C], LDL-C), lipoprotein (a) and a biomarker of inflammation High Sensitivity C-Reactive Protein (hsCRP). RYRE demonstrated a significant reduction in blood lipids and a positive impact on reducing the following
|Total Cholesterol||Decreased by 21%|
|LDL Cholesterol||Decreased by 30%|
|HDL Cholesterol||Increased by 16%|
|Triglycerides||Decreased by 25%|
|Lipoprotein A||Decreased significantly at all time points|
|High Sensitivity C-Reactive Protein||Decreased significantly|
RYRE is a source of natural statins. Statins are known to block an enzyme called HMG-CoA reductase, which is part of the Mevalonate pathway. By blocking this enzyme, statins reduce cholesterol biosynthesis but they also impact the body’s production of Coenzyme Q10 (also made through the Mevalonate pathway). Scientists examined the effects of statins on 30 subjects through a clinical trial utilizing two experimental arms: (Group A) 20 mg Simvastatin per day, and (Group B) 20 mg Simvastatin plus 100 mg CoQ10 per day. In the 90 day study, scientists observed that the Simvastatin exerted a significant decrease in blood lipids, but also reduced CoQ10 levels from 1.08 mg/dl to 0.80 mg/dl. On the other hand, the Simvastatin plus CoQ10 group actually experienced a significant increase of plasma CoQ10 (from 1.20 to 1.48 mg/dl) without affecting blood lipid impact of the statins. CoQ10 is an essential nutrient in energy synthesis and its supplementation is ideal in countering CoQ10 reduction from statins. View research
Red Yeast Rice Extract is fermented by monascus purperus in a standardized process to concentrate the bioactive compounds known as Monacolin K to a level of 0.4%. As Monacolins block biosynthesis of cholesterol and CoQ10, our Red Yeast Rice Extract is always paired with CoQ10. Reap the benefits of RYRE and C0Q10 in our Counter Cholesterol.